The Institute of Cancer Research at the Medical University of Vienna has discovered a new treatment for Mesothelioma. Mesothelioma is an asbestos related cancer. It is a rare primary tumor. This cancer develops and attacks cells in the tissue that lines and protects the body cavity called the mesothelium. Its most common site is the pleura (outer lining of the lungs and internal chest wall), this is called Pleural mesothelioma, but it may also occur in the peritoneum (the lining of the abdominal cavity) peritoneal mesothelioma, or the pericardium (a sac that surrounds the heart) pericardial mesothelioma. This cancer can take 30 to 50 years to present symptoms and often, once finally detected, is resistant to chemotherapy and radiation treatments. This prolonged latency period often leads to a late or delayed diagnosis. Each year, the disease causes an estimated 15,000 to 20,000 deaths worldwide.
Researchers in Austria, while pursuing a treatment for kidney cancer, have discovered a potential treatment for mesothelioma. Rapamycin (mTOR) is a protein that regulates cell growth. Temsirolimus, a kinase inhibitor, has been discovered to reduce the production of this protein and thereby slowing the growth of certain tumors. Temsirolimus also may slow the growth of malignant pleural mesothelioma cells. The researchers found that temsirolimus strongly blocked mTOR-mediated signals and had a cytostatic, or growth-stopping, effect on all mesothelioma cells. However mesothelioma cells that were resistant to cisplatin, a widely used chemotherapy drug, showed hypersensitivity against temsirolimus. These studies suggest that inhibitors such as tesirolimus may be effective in the treatment of mesothelioma either in conjunction with chemotherapy and radiation treatment or as a second line treatment should the cancer not respond to those traditional treatments which generally only prove to be effective for those diagnosed with stage 1 mesothelioma; less than 10%.
Clinical trials continue rendering favorable results and hope to both scientist and those individuals plagued with this disease.
Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles, or have been exposed to asbestos dust and fibre in other ways, such as by washing the clothes of a family member who worked with asbestos, or by home renovation using asbestos products. Many companies that manufactured asbestos containing products were aware of the potential harm that could result from the use of their product. As early as the 1920’s up until the mid 1970’s, companies chose to use asbestos without displaying warnings of the potential hazards. These companies share liability. If you have been diagnosed with mesothelioma, you may have the right to recover damages against those manufacturers.
Our mesothelioma dedicated attorneys at Reyes, O’Shea & Coloca, P.A are dedicated to the fight for the rights of these individuals who were unknowingly exposed and put at risk. Each case is handled individually and given the attention and priority it deserves by our carefully trained legal team.
Renal Cancer Drug Temsirolimus Shows Promise Against Mesothelioma
Journal of Thoracic Oncology, 2011; 6 (5): 852-863 DOI: 10.1097/JTO.0b013e31820e1a25