Articles Posted in Medical News

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Microscope ADVANCED_TRINOCULAR_RESEARCH_MICROSCOPE_RMH-4T.pngAccording to the American Cancer Society, malignant mesothelioma is a cancer that starts in the cells that line certain parts of the body, most commonly the lungs and stomach. The disease is predominately a result of exposure to asbestos and kills nearly 3,000 people each year. Because 3,000 is not as staggering as the approximately 200,000 people in the United States that get lung cancer, and more than 159,000 people that die from the disease, funding for research and the necessary attention that would promote public awareness is sometimes difficult to come by. However, there is a dedicated group that vehemently pursue a cure for mesothelioma.

Mesothelioma has no cure at this time. One of the key elements to effective management of the disease is early detection and an accurate prediction of how the cancer will respond to available treatments. Current research includes the search for an ideal biomarker that can aid in the diagnosis of the disease and help predict the effectiveness of various treatments including chemotherapy. A biomarker is a distinct biochemical, genetic, or molecular characteristic or substance that is an indicator of a particular biological condition or process. Obtaining the necessary tissue or tumor samples necessary for a diagnosis is often quite invasive. The majority of research thus far has been of a case-control design to determine diagnostic accuracy of particular molecules. In the past ten years substantial progress has been made in the identification of biomarkers specific to Malignant Pleural Mesothelioma. Future research will require the determination of how to integrate the information of the distinguished markers into clinical diagnostic and /or management algorithms.

Some recent studies have focused on the overexpression of the ephrin B2 receptor (EPHB2) in patients with mesothelioma. Ephrin type-B receptor 2 is a protein that in humans is encoded by the EPHB2 gene. In a sampling of 34 different malignant mesothelioma tumors, it was found that the EPHB2 was significantly higher in tumor tissue than in normal peritoneum and not in benign mesothelial cells. Continuing studies focus on determining the following:

  • If by using specific EPHB2 inhibitors it will slow the progression of the disease. Inhibiting growth increased the apoptotic proteins and activity, which is part of the natural self-destruction of cells. Stopping the growth of EPHB2 also decreased the proliferation and invasion of the bad cells, in the laboratory research.
  • If EPHB2 can be used as an effective marker for Malignant mesothelioma. Can EPHB2 be used for early detection and can monitoring the quantity thereof, determine the effectiveness of treatment.

Research is critical to the advancement of treatment and the search for a cure for Malignant Mesothelioma. Research which cannot take place without the requisite funding. Funding that, despite the admirable efforts of various charities, organizations, and dedicated individuals, always seems to be lacking. The Department of Defense Bill finally offers some assistance. The 2014 Defense Appropriations Bill (H.R. 2397), just recently approved by The House, includes funding for the Congressionally Directed Medical Research Program. The program includes the Peer Reviewed Cancer Research Program in which Mesothelioma is a topic area.

The quest for answers progresses.

The battle continues…
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GREEN TEA CUP.jpgTEA TIME: For years, doctors and scientists alike have touted the benefits of Green Tea. The positive effects of green tea can extend to just about everything from visible signs of aging, high cholesterol and weight loss to Alzheimer’s, HIV and cancers such as mesothelioma.

According to the American Cancer Society, malignant mesothelioma is a cancer that starts in the cells that line certain parts of the body, most commonly the lungs and stomach. Mesothelioma also can occur in the heart and testicles.

Green tea contains large quantities of an antioxidant called epigallocatechin-3-gallate (EGCG); no other form of tea only GREEN TEA. It has been discovered that EGCG caused cell death in five different human mesothelioma cell lines. Another significant finding was the breakdown of certain cell components as a result of stress induced by EGCG. This breakdown is known as autophagy. The mesothelioma cell lining, although damaged by the autophagy triggered by the ECGC, sustained effects more severe when the autophagy was suppressed.

GREEN TEA LEAF.jpgThe concept of green tea fighting malignant mesothelioma is not a new one. Last year The Journal of Cellular and Molecular Medicine published the findings of a Japanese team which stated that “EGCG is selectively cytotoxic to malignant mesothelioma cells..” In 2007 Researchers at the Center for Human Nutrition at the University of California at Los Angeles discovered that a green tea extract remodeled a certain protein in lung cancer cells that made the cells more likely to group and stay together and significantly less likely to spread.

The only possible NEGATIVE associate with green tea has been caffeine. According to the Mayo Clinic more than 500 to 600 mg a day of caffeine may cause insomnia, nervousness, restlessness, irritability, stomach upset, fast heartbeat and or muscle tremors. However, nearly every brand on the grocery store shelf carries a decaffeinated green tea. Therefore, the issue of caffeine is really a non-issue.

It has not been claimed to be the illusive cure for cancer or mesothelioma, but it appears that green tea kills cancer cells and inhibits the growth of additional cancer cells. The antioxidant in green tea is just about 100 times more effective than vitamin C and 25 times better than vitamin E. Consult your doctor to determine if green tea could have any medical benefits to you.
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stethoscope blue.jpgPleural Disease and Asbestosis are the two (2) non-malignant asbestos related conditions. For these two diseases, there are no cures at this time. Treatment is typically palliative care which is treatment that attempts only to reduce the severity of the symptoms, relieving and preventing discomfort and suffering and is not administered as curative medicine. Antimicrobial therapy can be administered if the disease results in an infection; however, drugs are not effective in the treatment of asbestosis or pleural disease. Corticosteroids and immunosuppressive drugs do not alter the course of the diseases.

Symptoms of asbestosis and pleural disease include the following:

  • Shortness of breath
  • A persistent and productive cough (a cough that expels mucus)
  • Chest tightness
  • Chest pain
  • Loss of appetite
  • A dry, crackling sound in the lungs while breathing in

Aerosol medications and/or oxygen can be administered to appease or mitigate the symptoms. Physical therapies can be implemented such as pounding your chest and back repeatedly with your hands or a device to loosen the mucus from your lungs so that you can cough up the phlegm. You may also sit with your head tilted down, or lay on your stomach with your head down to help drain the mucus from your lungs.

But the most important thing once diagnosed with an asbestos related condition is to prevent the progression of the disease. Avoid any additional exposure to asbestos or any carcinogens and do not smoke. Food, rest, and exercise are essential in maintaining good health which will help mitigate the symptoms of an asbestos related disease. Taking care of your body will inevitably result in better health which will help you to breath easier: Be mindful of good nutrition. A healthy diet consists of a balance of fruits, vegetables and proteins. The proper diet is key in maintaining muscle mass and body functions. Watch your sodium or salt intake Drink lots of fluids– six to eight glasses daily is the recommended amount unless your doctor has instructed otherwise. The average person needs about eight (8) hours of sleep every day. Your body needs this time to recuperate and .mend itself. If you find yourself tiered or fatigued during the day, take short naps An appropriate exercise routine will strengthen both your muscles and your heart and lungs – a critical part of breathing easy.

Maintain cleanliness. Keep yourself and your surroundings free of germs and bacteria. The lungs and lung functions of someone with asbestosis or pleural disease are already impaired. Prevent infection, and avoid the risk of colds and flu. Get flu and pneumonia shots annually which should be administered sometime between September and December.

Asbestosis and Pleural Disease are progressive diseases. It is imperative that you get annual physicals, maintain open communication with your doctor and continually monitor your condition. Individuals who have been diagnosed with a non-malignant asbestos related condition are at an increased risk of developing lung cancer, mesothelioma and other non-pulmonary malignancies such as colon cancer, stomach cancer, laryngeal cancer, pharyngeal cancer and esophageal cancer.
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Cancer-that-Affect-Children.jpgMesothelioma is a disease typically characterized by a very long latency period, 15 – 50 years, and exposure to asbestos. The most common form of exposure is occupational. Additionally, a large study found that people first exposed to asbestos before age 10 were less likely to develop mesothelioma than those who were exposed to the fibers later in life. Accordingly, a diagnosis of mesothelioma in a child is extremely rare.

There are certainly potential risks of asbestos exposure for children:

  • Secondhand exposure from a parent who worked with asbestos.
  • Asbestos in schools
  • Environmental asbestos (breathing the air or playing in/eating contaminated soil)
  • Asbestos in toys such as chalk, crayons and modeling clay

However, the actual percentage of children who have mesothelioma that can link the disease to asbestos exposure is relatively few.

Scientists and medical professionals alike concur that exposure to asbestos during childhood increases the risk of developing an asbestos related disease, such as mesothelioma, later in life. They further agree that almost all cases of mesothelioma can be linked to asbestos exposure, but some simply cannot. The question remains as to what exactly causes mesothelioma to manifest in children before the typical latency period and without the expected exposure to asbestos. Research is ongoing and scientists are analyzing all aspects of the disease. Similarities of the disease in children and adults are the symptoms and responses to treatments. Differences that are being analyzed include the fact that while most adults suffer from pleural mesothelioma, which is located in the lining of the lung, most children that suffer from the disease have peritoneal mesothelioma, which is a cancer in the abdominal cavity lining. Latency period is also a differentiating factor. Researchers are looking beyond the well-known link to asbestos exposure for links to this deadly disease: such as genetic predispositions or exposure to other drugs or chemicals including prenatal exposure to a drug known as isoniazid.

To date, there remains no cure. Children and adults are being stricken with the disease and have a life expectancy of only four (4) to eighteen (18) months. For both children and adults, early detection is of critical importance. Early detection in youths is even more difficult than in adults because it is so uncommon, that it is rarely an initial diagnosis. Additionally, peritoneal mesothelioma, which is the more common in young mesothelioma sufferers, requires significantly more testing to accurately diagnose.

The young and the older should always get regular check-ups. Never ignore symptoms, and speak openly with your doctor of any medical concerns.
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Mesothelioma is a devastating disease that is nearly always attributed to asbestos exposure. Between 2,500 and 3,300 people are diagnosed with mesothelioma every year. Although there is still no cure, current research offers hope with methods of early detection and treatments that can help mitigate some of the symptoms.

breathalyzer.jpgThe “electronic nose”: Researchers at the University of New South Wales in Australia have created a non-invasive breath test that is capable of distinguishing malignant and non-malignant asbestos related diseases. By analyzing the volatile organic compounds (vocs) in exhaled breath, it can accurately diagnose asbestos related conditions. In a study of 50 patients with both mesothelioma and benign asbestos related diseases “the nose” accurately identified 88% of the patients. This device, which is very similar to the current breath test used in traffic/suspected DUI cases, has the potential to non-invasively diagnose mesothelioma , with-out the standard blood tests, bronchoscopies or biopsies that can be quite painful and may lead to any of various complications. Early detection is critical when it comes to treating and beating this highly aggressive cancer. We are now one step, or at least one BREATH, closer to a cure.

moles.jpgAnother way to detect the risk of mesothelioma is through skin lesions. Studies have shown that specific skin spots may be an indicator of the increased risk of mesothelioma. Researchers at the University of Hawaii say that these mole-like tumors have a mutation in the BAP1 gene, which has been linked to a higher susceptibility to developing mesothelioma. With the mutation of this gene, the body’s natural cancer-suppressing functions are hindered and do not function properly or sufficiently. The appearance of the mole is likely to occur before the symptoms of mesothelioma begin to present. Biopsy and pathology would need to be done on the skin or tissue sample to confirm the existence of the specific characteristics that are unique to this gene mutation. Once confirmed, this can lead to early detection and diagnosis of mesothelioma, which can lead to early treatment and a significantly greater chance of survival.

CANNIBUS plant.jpgOnce diagnosed with mesothelioma, chemotherapy and radiation are the most common treatments designed to stop or at least inhibit the progression of the tumor. Scientists, Sean McAllister and Pierre Desprez, say that their research indicated marijuana can stop metastasis in certain cancers including mesothelioma. Marijuana, although still a prohibited substance, has been approved as a medicinal means to fight nausea and stimulate appetite, to control and/or treat glaucoma, schizophrenia, convulsions and neurological disorders. Now it has been found that the marijuana plant, more specifically the compound cannabidiol found in the marijuana plant, has the ability to stop the expression of the Id-1, a gene protein often responsible for the metastasis of cancers. Clinical trials are pending, but the scientists have already begun synthesizing the cannabidiol in the lab in hopes of avoiding any potential legal complications in getting the drug approved.

If you think you may be at risk for mesothelioma or any asbestos related disease, seek advice from a medical professional. Routine medical check-ups and open communication with your primary care physician are an essential part of maintaining good health.
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Thumbnail image for heart organ.jpgIt is widely known that asbestos causes pulmonary diseases such as asbestosis and pleural disease and malignancies such as colon cancer, esophageal and laryngeal cancers, stomach cancer, lung cancer and mesothelioma. According to the latest studies performed by the Health and Safety Laboratory in Buxton, Derbyshire, individuals exposed to asbestos during their working life are also significantly more susceptible to heart disease and stroke.

Researchers evaluated a group of 99,680 asbestos workers that were monitored for an average of 19 years. A total of 15,557 workers died during the study period. 1,053 of these deaths resulted from stroke and 4,185 were due to heart disease.

It was found that male asbestos workers were 63 percent more likely to die from stroke than the general population and 39 percent more likely to die of heart disease. For woman the statistics rose to a startling 100 percent and 89 percent respectively. It was also noted that the duration of exposure was commensurate with the risk of dying from heart disease.

The Study:
A group of 98,912 asbestos workers took part in a voluntary medical surveillance for the early detection of asbestos related disease. Personal information such as age and gender as well as data such as duration of occupational exposure to asbestos, job type and smoking history was logged and updated for a nineteen year period. These individuals were flagged for death registrations with the National Health Service Central Register so that a cause of death could also be ascertained. Ninety-eight percent (98%) of the workers were successfully traced.

The Findings:
Comparing mortality among the asbestos workers with that of the Great Britain population demonstrated a significant excess of deaths among men and women for both cerebrovascular and heart disease, both overall and within each smoking status category. The analysis showed that the increase in risk of heart disease with age and with duration of exposure to asbestos was greater amongst never-smokers than among current smokers. These findings provide some evidence that occupational exposure to asbestos was associated with cardiovascular disease mortality in this group of workers.

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Despite these new findings, heart disease and stroke are still NOT compensable injuries. Bankruptcy trusts as well as non-bankrupt companies still do not recognize heart disease as an asbestos related disease nor do they offer settlement funds to those who have suffered a stroke. Perhaps with additional studies and evidence of the link between asbestos exposure and heart disease and stroke, these victims of asbestos exposure too will be allowed to seek compensation.
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Photinus_pyralis_Firefly_glowing.jpgResearchers at Memorial Sloan-Kettering in New York have just recently released the results of one of their latest studies of an oxidative enzyme derived from fireflies called Firefly Luciferase. This enzyme is responsible for the bioluminescence of fireflies. Researchers discovered, after treating mesothelioma cells with this enzyme, that heat-based treatments may be effective against mesothelioma and that firefly luciferase can be a valuable guidance system. The specially treated cancer cells emitted a bright, clear, bioluminescent signal that amplified with the cell number and was detectable with as few as 10 cells in cell culture. In other words, when the enzyme is isolated and treated, it can be made to bind with certain biomarkers, causing cells with these markers to glow. This is a high-tech, glow in the dark, cancer tracker; courtesy of Mother Nature.glowing-cancer-cells-mouse.jpg

Scientists were able to inject the tumors of laboratory mice and the compound only attached itself to the malignant cells (those with the designated biomarkers). As a result, ONLY the malignant cells were illuminated on the post procedure radiological tests.

Electrocautery is a surgical technique which involves introducing high frequency current to a specific area of the body in order to remove unwanted tissue, seal off blood vessels, or to create a surgical incision. Ablation is a medical technique used to remove tissue from the body through radio-wave frequencies. It is used to treat many different medical problems including malignant tumors. If the desired target (mesothelioma cells) are illuminated (like fireflies in the night) they are significantly easier to identify and subsequently destroy and or remove using electrocautery ablation.

Bioluminescence imaging is a sensitive, real-time imaging approach; bioluminescence reporters such as firefly luciferase can assess and guide thermal treatment of cancer. This encourages research into bioluminescence imaging as a molecular technique with potential to target tumors via biomarkers and optimize thermal treatment procedures in a clinical setting.

This breakthrough offers the possibility of identifying the cells of a mesothelioma tumor without the need for invasive surgery and subsequently being able to treat the cancer more precisely and aggressively; each cell and only those diseased cells, unquestionable malignant mesothelioma, can be treated and or removed.

Mesothelioma is a rare form of cancer caused by asbestos exposure. Its most common site is the pleura (outer lining of the lungs and internal chest wall), but it may also occur in the peritoneum (the lining of the abdominal cavity), and the pericardium (a sac that surrounds the heart). Three thousand people die each year from this devastating disease.
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medical-records1.jpgDiagnosing mesothelioma is very difficult, and cases of mesothelioma misdiagnosed are unfortunately not uncommon.

Malignant mesothelioma is cancer that starts in the cells that line certain parts of the body, especially the chest and belly (abdomen). The lining formed by these cells is called mesothelium. These cells protect organs by making a special fluid that allows the organs to move. For instance, this fluid makes it easier for the lungs to move during breathing.

The mesothelium has different names in different parts of the body:

  • In the chest it is called the pleura.
  • In the belly it is called the peritoneum.
  • In the space around the heart it is called the pericardium.

Tumors of the mesothelium can be benign or they can be cancer. A cancer tumor of the mesothelium is called a malignant mesothelioma, but this is often shortened to just mesothelioma. About 3 out of 4 mesotheliomas start in the chest cavity. These are called pleural mesotheliomas. Another 10%-20% begin in the abdomen (belly). These are called peritoneal mesotheliomas. Those starting around the heart are very rare. This cancer can also start in the tissue around the testicles, but this is also very rare.

pleural-mesothelioma.jpgPleural mesothelioma (tissue surrounding the lungs)

  • Shortness of breath
  • Coughing, often painful
  • Unexpected and unexplained loss of weight
  • Pain under the rib cage
  • Sometimes lumps may be detectable under the skin in the chest area
  • Lower back pain
  • Discomfort in the side of the chest
  • Exhaustion
  • Some people may experience sweating, fever, or difficulty swallowing

peritoneal-mesothelioma.jpgPeritoneal mesothelioma (lining in the abdomen)

  • Unexplained weight loss
  • Pain in the abdomen
  • Swelling in the abdomen
  • Lumps in the abdomen
  • Nausea, some patients may experience vomiting

Pericardial mesothelioma (lining in the heart area)

  • Low blood pressure
  • Chest pain
  • Shortness of breathheart image small.jpg
  • Fluid retention (edema), often in the legs
  • Heart palpitations
  • Fatigue, extreme after light exertion

As you will note, none of these symptoms are rare or sufficiently unique that it would preclude a diagnosis other than Mesothelioma. Because mesothelioma’s symptoms are not unique to it and the disease’s relative rarity, cases of mesothelioma misdiagnosed are not uncommon. A review of the patient’s medical and work history is an important part in assessing the risk of mesothelioma. It is important to share your case history of work experience (especially in shipyards and at construction sites) and asbestos exposure potential with your physicians if you feel mesothelioma is a risk. Asbestos fibres can also be carried into the home on clothing, inadvertently exposing the deadly fibres, and the risk of mesothelioma, to family members.

In addition to being misdiagnosed as a less severe Asbestos related disease such as Pleural Disease or a Lung cancer / adenocarcinoma Mesothelioma has been mistakenly diagnosed as:

  • Ovarian cancer
  • Respiratory infection
  • Tuberculosis
  • Heart failure
  • Viral pneumonia (type of Pneumonia)
  • Lingering cold
  • Emphysema
  • Pleural adenocarcinoma
  • Bowel disease
  • Bowel obstruction
  • Lyme disease
  • Pleurisy

3,000 people are diagnosed with mesothelioma cancer each year, and the average age of people afflicted is between 50 and 70 years or older. Mesothelioma cancer is most strongly associated with exposure to asbestos, and can remain latent in those exposed for 30 to 40 years. The facts that Mesothelioma is more prominent among the elderly, who often suffer from a variety of age related symptoms and that their asbestos exposure so long ago may have been forgotten or seem irrelevant also make it more difficult when diagnosing Mesothelioma.

Although the symptoms are not distinct or unique, the treatment for Mesothelioma is. This form of cancer does not respond well to standard radiation or chemotherapy treatments. This is why it is imperative to make an early diagnosis. A diagnosis in the early stages of any cancer is always key in enhancing and extending survival rates. A misdiagnosis can delay treatment and rob the patient of precious time. Moreover, a misdiagnosis prevents the injured party from seeking compensation from the culpable parties. A correct and concise diagnosis of an asbestos related disease is imperative when seeking to file claims within the judicial system or the bankruptcy courts.
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Anxiety_sml.jpgPsychological stress refers to the emotional and physiological reactions experienced when an individual confronts a situation in which the demands go beyond their coping resources. A diagnosis of Mesothelioma is certainly overwhelming, both mentally and physically. Dealing with the physical symptoms, which usually include loss of breath, the medical treatment and side effects there-of, the legal questions that arise from the diagnosis of this asbestos related disease as well as the personal and emotional trauma is all too often an insurmountable amount of stress. This often leads to severe depression, anxiety and feelings of isolation. Recent studies show that often treating oncologists are not equipped to diagnose the psychological ramifications of the disease.

The body responds to stress by releasing stress hormones, such as epinephrine (also called adrenaline) and cortisol (also called hydrocortisone). These hormones accelerate blood pressure and heart rate and raise blood sugar levels and; therefore, increase or enhance speed and strength to help deal with the stressful situation. Although small amounts of stress are believed to be beneficial, high levels of stress over extended periods of time are harmful.

Stress, depression, anxiety All have a NEGATIVE impact on treatment and the quality of life; which is so very important when dealing with what is typically a fatal disease. They also typically can lead to any number of the following:

  • Persistent sadness almost every day for most of the day
  • Loss of appetite or overeating, developing significant weight loss or gain
  • Nausea and/or vomiting
  • Loss of interest in once desirable activities
  • Insomnia or oversleeping (not related to treatment exhaustion)
  • Thoughts of death or suicide, attempting to commit suicide
  • Feelings of guilt or worthlessness
  • Restlessness, lack of energy, constant fatigue
  • Denial of obvious tension or anxiety
  • Appearing tense
  • Mental confusion – Difficulty solving basic problems
  • Trembling or shaking
  • Headaches or migraines
  • Agitation and aggressive behavior

Psychology-Symbol.gifThere are positive and negative aspects to the psychological treatment of Mesothelioma. Psychologists act as counselors, therapists, friends and sometimes a necessary shoulder to cry on during this tough time in a patient’s life. Even with all the overwhelming appointments a patient may have on their plate, psychologists are trained to help them make sense of this, sometimes sudden, life altering change. Psychologists and psychotherapy offer an outlet for the patient to express the whirlwind of emotions that are an inevitable part of this serious and often terminal diagnosis. The downside is that therapy does not offer instant gratification. It is an ongoing process that often requires a substantial amount of time. This is why the psychological needs of a mesothelioma patient are commonly addressed with both a therapeutic and pharmacological approach. In addition to counseling and support groups, there are a variety of anti-anxiety and anti-depression drugs that can prove invaluable.

Simply stated by Harvey Max Chochinov MD PhD; “I think it’s fair to say that every patient who is faced with a cancer diagnosis will have a profound emotional response or reaction to the news. It is particularly distressing in the early diagnostic phases when people are dealing with all kinds of uncertainties”.

Support Groups for Mesothelioma

Nearly half of all patients with an advanced form of cancer like mesothelioma experience emotional distress like fear, anger, depression and anxiety. But patients with a strong social support network have a lower risk for developing these symptoms. An important component to developing and maintaining such a network is through participation in support groups. Mesothelioma support groups are often arranged by local hospitals, therapists or cancer advocacy groups such as the American Cancer Society and the American Psychological Oncological Society . Groups can be casual or structured, and they can meet in public places or over the telephone or internet. Some groups offer spiritual support, while others focus more on education and awareness.
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Mesothelioma, more precisely malignant mesothelioma, is a rare form of cancer that develops from the protective lining that covers many of the body’s internal organs, the mesothelium. It is known to be caused by exposure to asbestos. Its most common site is the pleura (outer lining of the lungs and internal chest wall), but it may also occur in the peritoneum (the lining of the abdominal cavity), the pericardium (a sac that surrounds the heart), or the tunica vaginalis (a sac that surrounds the testis).

The most common form of treatment for mesothelioma is radiation and chemotherapy, but the side effects are severe. According to the National Cancer Institute, side effects from chemotherapy include:

    Chemotherapy bottle.jpg

  • Anemia
  • Fatigue
  • Hair loss
  • Nausea and vomiting
  • Joint Pain
  • Swelling
  • Skin irritation

These are only to name a few.

Anti-angiogenesis drugs are relatively new. Those that have been used in animal studies have been successful in shrinking and killing cancerous cells. Although anti-angiogenesis drugs are yet to prove as successful in human studies, they are expected to yield similar results with significantly fewer side effects. Two anti-angiogenesis drugs receiving a great deal of attention are Veglin and Avastin. Veglin is designed to target a wide range of cancers, including malignant mesothelioma and renal cell carcinoma, while Avastin is designed primarily to target cancers of the colon and rectum. Learn more about Anti-Angiogenesis.

VEGLIN is a newly developed anti-angiogenesis non-chemotherapy drug that is in phase II of its ongoing clinical trial at the University of Southern California’s Keck School of Medicine. As an anti-angiogenesis drug, Veglin’s aim is to prevent angiogenesis, the physiological process by which new blood vessels are formed from pre-existing vessels. Angiogenesis plays a key role in growth and spread of tumors because the newly developed blood vessels feed tumors oxygen and nutrients necessary for metastasis. Learn more about Veglin. Veglin lowers the levels of Vascular Endothelial Growth Factors (VEGF – proteins that instigate angiogenesis), inhibiting cellular growth and stabilizing / reducing cancerous tumors. Phase I clinical trial results showed that Veglin was successful in lowering blood levels of VEGF in a significant number of patients.

PXD101 is an orally administered histone deacetylase inhibitor that is being used as a second line therapy in treating patients with mesothelioma that cannot be removed with surgery. It is an anti-angiogenesis drug treatment that is being used in clinical trials across the United Stated including the Yale Cancer Medical Center. Heading the research into this drug at Yale is Dr. Scott Gettinger, a medical oncologist in the Thoracic Oncology Program (TOP) at Yale who has gotten PXD101 into Phase 1 of FDA clinical trials. Although not the same for every patient the most common side effects of PXD101 include being tired and/or fatigued, along with low-grade nausea, which can be treated with medications. These side effects have proven to be minimal and less severe than the effects of chemotherapy or radiation.
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